CpG Oligodeoxynucleotide Market - Size, Share, Outlook, and Forecast till 2026

CpG Oligodeoxynucleotide

CpG oligodeoxynucleotides (CpG ODN) are short single-stranded synthetic DNA molecules that contain one of each of the following, cytosine triphosphate deoxynucleotide and guanine triphosphate deoxynucleotide, which make up for the C component in the molecule. The p component is due to the phosphodiester link between consecutive nucleotides, although some ODN have a modified phosphorothioate (PS) backbone instead. When these CpG motifs are unmethylated, they act as immunostimulants. CpG motifs are considered pathogen-associated molecular patterns (PAMPs), as they are abundant in microbial genomes, however, they are highly rare among vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor (PRR) Toll-Like Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher primates.

Synthetic CpG ODN differs from microbial DNA, as they have a partially or completely phosphorothioated (PS) backbone instead of the typical phosphodiester backbone and a poly G tail at the 3' end, 5' end, or both. PS modification protects the ODN from being degraded by nucleases such as DNase in the body and poly G tail enhances cellular uptake.

In 1995, CpG motif within bacterial DNA was demonstrated to be responsible for the immunostimulatory effects and developed synthetic CpG ODN. Ever since, various research companies have been targeting synthetic CpG ODN due to the Type I pro-inflammatory response it elicits and its successful use as vaccine adjuvants.

Increasing demand for vaccination in turn, is increasing the demand for CpG Oligodeoxynucleotides market. Furthermore, increasing prevalence of new diseases and the demand for reducing the occurrence of childhood diseases such as polio in turn, is expected to drive effective vaccines. This in turn, is expected to drive growth of the CpG Oligodeoxynucleotides market.

CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. It is thus, used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv, however are TLR9-Antagonists and have immunosuppressive effects. This is also contributing to growth of the CpG Oligodeoxynucleotides market.

The CpG Oligodeoxynucleotides market comprises of a few players involved in R&D for the development of novel drugs. Novus Biologicals was a biotech company based in Littleton, Colorado, USA with offices in San Diego, California, Oakville, ON, Canada and the Cambridge Science Park in Cambridge, UK.

Techne Corporation announced today that it has acquired Novus Biologicals for $60 million in cash. The transaction was financed with cash on hand.

Novus Biologicals is a Littleton, Colorado-based supplier of a large portfolio of both outsourced and in-house developed antibodies and other reagents for life science research.  Their collection of greater than 250,000 high-quality products delivered through an innovative digital commerce platform provides customers a unique, one-stop shopping experience.

 

Global and Chinese CpG Oligodeoxynucleotide Industry, 2018 Market Research Report

Published Date : May 2018

The 'Global and Chinese CpG Oligodeoxynucleotide Industry, 2013-2023 Market Research Report' is a professional and in-depth study on the current state of the global CpG Oligodeoxynucleotide industry with a focus on the Chinese market. The report provides key statistics on the market status of the Cp...

Global CpG Oligodeoxynucleotide Market Professional Survey Report 2018

Published Date : Nov 2017

This report studies CpG Oligodeoxynucleotide in Global market, especially in North America, China, Europe, Southeast Asia, Japan and India, with production, revenue, consumption, import and export in these regions, from 2012 to 2016, and forecast to 2022. This report focuses on top manu...

EMEA (Europe, Middle East and Africa) CpG Oligodeoxynucleotide Market Report 2017

Published Date : Dec 2017

In this report, the EMEA CpG Oligodeoxynucleotide market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. Geographically, this report split EMEA into Europe, the Middle East and Africa, With s...

Global CpG Oligodeoxynucleotide Market Research Report 2017

Published Date : Nov 2017

In this report, the global CpG Oligodeoxynucleotide market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. Geographically, this report is segmented into several key Regions, with production, ...

Global CpG Oligodeoxynucleotide Market Professional Survey Report 2017

Published Date : Sep 2017

This report studies CpG Oligodeoxynucleotide in Global market, especially in North America, China, Europe, Southeast Asia, Japan and India, with production, revenue, consumption, import and export in these regions, from 2012 to 2016, and forecast to 2022. This report focuses on top manu...

 

Select Licence :

  • Single User : $4500
  • Multiple User : $7000
  • Corporate User : $10000

Happy To Assist You

Assist you at Worldwide Market Reports

We will be happy to help you find what you need. Please call us or write to us:

Worldwide Market Reports Benefits

Custom Research Solution

Talk to our research consultant to design an exclusive report as per your research needs.

Customer Fulfilment

We aim to fulfil client's research demands with tailored research solutions.

Quick Turnaround Time Reports

We aim to provide research studies in quickest turnaround time and in a much cost effective manner.

360-degree Approach

We cover each industry from supply and demand side with an aim to provide a most holistic research study.