Novel Therapy For Glioblastoma brain cancer displays positive outcomes

Jun, 2021 - By WMR

Lisavanbulin is amongst the several novel drugs in progress designed for inhibiting tumor growth along with treating this devastating cancer form.

Recently announced results of an initial clinical trial analyzing a kind of novel drug for brain cancer drug revealed extremely promising responses within a specific patient subset. A bigger Phase 2 trial is currently underway pursuing patients having a particular biomarker. Glioblastoma is often a deadly and aggressive brain cancer form, with survival of just nearly 5% patients more than 5 years after first diagnosis. The Lisavanbulin is amongst the several novel drugs in progress designed for inhibiting tumor growth along with treating this devastating cancer form.

Data of long-term from a newly completed human trial of Phase 1 initially exposed mixed results, with just two among 20 patients displaying significant improvements. However, after a closer look at this data, the scientists found those 2 successful cases had a specific characteristic. The two patients were discovered of having a particular protein’s high expression known as end-binding protein 1 (EB1) within their tumor’s tissue. Three among the 20 subjects of this initial trial displayed strong expression of EB1. Preclinical studies even found positivity of EB1 was a solid efficacy predictor. After these results a trial of Phase 2 is presently underway focusing specifically on patients of glioblastoma with tumors that are EB1-positive.

Latest findings showed at the latest American Society of Clinical Oncology (ASCO) Annual Meeting specify EB1 expression could be present in approximately 5% cases of glioblastoma. The research even looked at the expression of EB1 in the number of other samples of cancer, finding it in little levels within certain metastatic melanoma, breast cancer and lung cancer tissues. Amongst this early trial’s patients, Paul Nicholson, experienced a shrinkage in his cancer by over 80 %. After three years his scans still look positive. The international Phase 2 trial’s Initial results are expected towards the end of this year.