Jun, 2022 - By WMR
Researchers developed a nasal spray that prevents Alzheimer’s by targeting a new brain mechanism that is assumed to drive the disease
A team of researchers at Neuro-bio developed a nasal spray that prevents neurodegeneration related to Alzheimer’s disease. As reported by the team, the novel treatment successfully reversed the pathological signs of Alzheimer’s in mice and the scientists are now planning to commence human trial for this nasal spray in next two years.
In this new research the scientists focused on targeting the mechanisms that drive the buildup of toxin proteins amyloid and tau in the brain. According to the scientists when these toxin proteins start build up in the brain and cause damage to neurons it becomes really difficult to stop or reverse this process with the use of drugs. In the alternative hypothesis of this research, the T14 brain chemical could be an earliest pathological drivers of Alzheimer’s and it is an important molecule for the development of brain in early stages however, is suspected of becoming toxic later. In past studies it was indicated that toxic levels of T14 in isodentritic core of the brain could be an early pathological sign of the disease. Thus, based on this knowledge, the team developed a new molecule called NBP14 to tackle the disease.
When tested in animal models of Alzheimer’s. The nasal spray formulation of this molecule NBP14 showed promising results with decreased levels of amyloid in mice brain with six weeks use of the molecule and the animals showed improvements in cognitive functions after 14 weeks that were similar to normal healthy mice. However, the drug needs more work before bringing it into human trials. Nevertheless, this type of treatment is far away from using it in real-world settings.
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