Aug, 2022 - By WMR
Researchers discovered that both children and elderly persons prefer oil based medications with a moderate flavour. The gels' ability to distribute hydrophobic drugs for infectious diseases.
Taking tablets might be challenging for people who have trouble swallowing. This is also true for many kids, who find it difficult to swallow big medicines meant for adults. Although many medications won't disintegrate in water, diluting a drug with a liquid may be helpful. Further, it can be difficult to obtain clean water in low-resource areas of the world to combine with drugs, and it can be problematic to store water-based medicine solutions where there is little or no access to refrigeration. Such water-based medication formulations are susceptible to spoilage without cold storage.
Oleogels, the name for the gels, can be modified to create a variety of textures, from runny yogurt-like things to considerably thicker things that resemble protein drinks. However, their ability to disintegrate hydrophobic medicines is their most important quality. The MIT and BWH researchers have used oil-based gels, which have a number of benefits as an easily ingested carrier medium for oral medications. According to Giovanni Traverso, a researcher engaged in the study, considering the system's ease of use and inexpensive cost, it may significantly improve patients' ability to take their pills.
The research team put different gels to the test to see which ones tasted the best. The mild nutty flavour of those produced with sesame oil has so far been discovered to be preferable. However popular gels at the time included those with a more bland flavour, like those prepared with cottonseed oil. The capacity of the gels to administer hydrophobic medications for infectious disorders, which would be especially pertinent in low-resource areas, has also been examined by the researchers. These include the anti-parasitic medication praziquantel, the anti-bacterial medication azithromycin, and the anti-malarial medication lumefantrine. The gel worked well as a delivery method in each scenario.