News

Genes of “Super-Centenarians” and its DNA Repair Mechanism

May, 2021 - By WMR

Genes of “Super-Centenarians” and its DNA Repair Mechanism

A DNA repair machinery and lower chances of mutation, as of proper functioning of the above mentioned genes are the underlying mechanism for which the supercentenarians are having extended longevity and  getting super protection from different age related disorders.

Aging is one of the most common factor, associated with each and every organism. Aging happens as every cell, which, make up the overall constitution of an organism, undergoes cell-cycle arrest. This cell-cycle arrest is characterized by damage or malfunctioning of DNA. However, this DNA damage is also very common in case of healthy cell, in day to day life, for which, every organism has got a DNA repairing mechanism.

Recently a scientific discovery stated that people having an extraordinary timeline of almost more than 105 years, have developed a mechanism in which their DNA repairing mechanism is more efficient than a normal healthy man.

For the first time, the genome of such people have been isolated and sequenced in such details. The sequencing data might serve as a template not only for the underlying DNA repair mechanism but also to clinical expression of several age-related diseases and their possible therapeutic outcome too.

The study was conducted, focusing on mainly two generation. First population of genome was selected from the younger age population, as these group of people tend to have lesser susceptibility towards age related disorder. And the other population of genome was taken from a group of people having life beyond 105 years. Blood samples were from all of them to analyze and sequence the whole genome.

A common genetic change was found in the age group of around 105 years, encompassing mainly two genes, STK17A and COA1. Out of these two, the STK17A expression has been increased in several areas of the body, like managing the production of Reactive Oxygen Species (ROS), cellular response to the damaging DNA and induction of the senescent cells in the apoptotic (programmed cell death) pathway. Genetic changes were also found in the gene COA1, which responsible for the energy metabolism of the body and the cell to cell contact.

Happy To Assist You

Contact Images

We will be happy to help you find what you need. Please call us or write to us:

Contact us

mapicon
Sales Office (U.S.):
Worldwide Market Reports, 1001 4th Ave, #3200 Seattle, WA 98154, U.S.

mapicon+1-415-871-0703

mapicon
Asia Pacific Intelligence Center (India):
Worldwide Market Reports, 403, 4th Floor, Bremen Business Center, Aundh, Pune, Maharashtra 411007, India.

Newsletter

Want us to send you latest updates of the current trends, insights, and more, signup to our newsletter (for alerts, special offers, and discounts).


Secure Payment By:
paymenticon

This website is secured Origin CA certificate on the server, Comodo, Firewall and Verified Sitelock Malware Protection

secureimg

© 2021 Worldwide Market Reports. All rights reserved