News

Danger Molecule HMGB1 Is High Among Obese, Female, and Black Young Adults, Study Suggests

Feb, 2021 - By WMR

Danger Molecule HMGB1 Is High Among Obese, Female, and Black Young Adults, Study Suggests

According to a new study led by the researchers of Medical College of Georgia have reported that High Mobility Group Box-1 or HMGB1 also known as 'danger molecule' level is higher in the blood of younger black adults, in comparison to whites, it is much more significant in females in comparison to males and further upsurges with weight and age. Moreover researchers have associated HMGB1 levels with obesity, inflammation promoters, and as an early indicator of cardiovascular risk in humans.

Researchers highlights the potential of circulating HMGB1 levels to act as biomarker of cardiovascular risk and application of HMGB1 antibodies or inhibitors in preventing or treating obesity, chronic inflammation, and cardiovascular disease. HMGB1 are damage-associated molecular patterns, or DAMPs have a positive role, when it is inside the nucleus or cytoplasm of cells. However, when HMGB1 is released by injured or stressed cell activates an immune response that spreads and induces chronic state of inflammation.

In the study, researchers involved 489 individuals with an average age of 25 and four blood samples were drawn over the duration of 8.5 years. Later, after the evaluation, researchers observed that obese people exhibited high levels of HMGB1 over time, especially in individuals with a high waist-hip ratio.

Moreover, researchers also noted that blood levels of HMGB1 was higher in black individuals and females and remained higher throughout the entire duration of 8.5 years, indicating that blacks individuals are at higher risk for developing severe cardiovascular and cerebrovascular problems at an younger age, in comparison to whites.

Chen stated, “Females tend to be healthier than males by a lot of markers. But this one is in the opposite direction. At least before menopause, females tend to have fewer cardiovascular problems than males. The researchers suspect that generally higher percentages of body fat in females might help explain the higher HMGB1 levels, but that younger females may have unique cardiovascular protections, like estrogen.”

Happy To Assist You

Contact Images

We will be happy to help you find what you need. Please call us or write to us:

Contact us

mapicon
Sales Office (U.S.):
Worldwide Market Reports, 1001 4th Ave, #3200 Seattle, WA 98154, U.S.

mapicon+1-415-871-0703

mapicon
Asia Pacific Intelligence Center (India):
Worldwide Market Reports, 403, 4th Floor, Bremen Business Center, Aundh, Pune, Maharashtra 411007, India.

Newsletter

Want us to send you latest updates of the current trends, insights, and more, signup to our newsletter (for alerts, special offers, and discounts).


Secure Payment By:
paymenticon

This website is secured Origin CA certificate on the server, Comodo, Firewall and Verified Sitelock Malware Protection

secureimg

© 2021 Worldwide Market Reports. All rights reserved